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2565705-01-1

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2565705-01-1 Structure

2565705-01-1 Structure
IdentificationBack Directory
[Name]

1,2-Benzenediamine, N1-[(S)-(3-chloro-2-pyridinyl)(2,2-difluoro-1,3-benzodioxol-4-yl)methyl]-N2-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-(methylsulfonyl)-
[CAS]

2565705-01-1
[Synonyms]

1,2-Benzenediamine, N1-[(S)-(3-chloro-2-pyridinyl)(2,2-difluoro-1,3-benzodioxol-4-yl)methyl]-N2-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-(methylsulfonyl)-
[Molecular Formula]

C25H21ClF2N6O6S
[MOL File]

2565705-01-1.mol
[Molecular Weight]

606.99
Chemical PropertiesBack Directory
[Boiling point ]

727.4±70.0 °C(Predicted)
[density ]

1.59±0.1 g/cm3(Predicted)
[pka]

2.96±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

Dot1L-IN-6 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 SPA DOT1L of 0.19 nM[1].
[in vivo]

Dot1L-IN-6 (Compound 9) shows an excellent blood exposure after a single dose (100 mg/kg)[1].

[References]

[1] Frédéric Stauffer, et al. New Potent DOT1L Inhibitors for in Vivo Evaluation in Mouse. ACS Med. Chem. Lett. 2019, 10, 12, 1655-1660.
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