| Identification | Back Directory | [Name]
CHO-Ph-PEG5-amine TFA | [CAS]
2566404-73-5 | [Synonyms]
CHO-Ph-PEG5-amine TFA
CHO-Ph-CONH-PEG5-azide | [Molecular Formula]
C20H30N4O7 | [MDL Number]
MFCD32901498 | [MOL File]
2566404-73-5.mol | [Molecular Weight]
438.48 |
| Hazard Information | Back Directory | [Uses]
N3-PEG5-aldehyde is a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. N3-PEG5-aldehyde is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
Cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
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