| Identification | Back Directory | [Name]
Antitumor agent-68 | [CAS]
2566497-96-7 | [Synonyms]
Antitumor agent-68
2-Propynoic acid, 3-phenyl-, 1H-indol-5-yl ester | [Molecular Formula]
C17H11NO2 | [MOL File]
2566497-96-7.mol | [Molecular Weight]
261.27 |
| Hazard Information | Back Directory | [Uses]
Antitumor agent-68 is a potent tubulin inhibitor. Antitumor agent-68 shows potent anticancer activity with IC50s of 3.6 and 3.8 μM for HeLa and MCF-7 cells, respectively. Antitumor agent-68 exhibits good scavenging activity of ROS and DPPH radical in a dose-dependent manner[1]. Antitumor agent-68 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [References]
[1] Domenico Iacopetta, et al. Synthesis, anticancer and antioxidant properties of new indole and pyranoindole derivatives. Bioorg Chem.?2020 Dec;105:104440. DOI:10.1016/j.bioorg.2020.104440 |
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