| Identification | Back Directory | [Name]
Benzamide, N-[[2-fluoro-4-[[[(1S,2S)-2-(3-pyridinyl)cyclopropyl]carbonyl]amino]phenyl]methyl]-4-(1-piperazinyl)-, 2,2,2-trifluoroacetate (1:) | [CAS]
2567724-20-1 | [Synonyms]
Nampt-IN-10 TFA
Benzamide, N-[[2-fluoro-4-[[[(1S,2S)-2-(3-pyridinyl)cyclopropyl]carbonyl]amino]phenyl]methyl]-4-(1-piperazinyl)-, 2,2,2-trifluoroacetate (1:) | [Molecular Formula]
C29H29F4N5O4 | [MOL File]
2567724-20-1.mol | [Molecular Weight]
587.58 |
| Hazard Information | Back Directory | [Uses]
Nampt-IN-10 TFA (compound 4) is a Nicotinamide Phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-10 TFA shows cellular potency to A2780 and CORL23 cells lines with IC50s of 5 and 19 nM, respectively. Nampt-IN-10 TFA can be used as a novel non-antimitotic payload for ADCs[1]. | [References]
[1] Karpov AS, et al. Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody-Drug Conjugates. ACS Med Chem Lett. 2018 Jun 28;9(8):838-842. DOI:10.1021/acsmedchemlett.8b00254 |
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