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MRS2768 tetrasodium salt is a moderately potent and selective P2Y2 receptor agonist. MRS2768 tetrasodium salt has a protective effect on cardiomyocytes from ischemic damage in vivo and in vitro[1][2]. | [in vivo]
MRS2768 (4.44 μg/kg i.v.) pretreatment reduces myocardial damage in mice. MRS2768 has a protective effect on cardiomyocytes from ischemic damage in vivo[2]. | Animal Model: | Male wild-type mice (C57BL)[2] | | Dosage: | 4.44 μg/kg | | Administration: | Injected i.v.; 1 h before myocardial infarct (MI) | | Result: | Pretreatment reduced myocardial damage. The damage was significantly smaller in mice compare to the untreated mice (25.6±4.5% vs. 39.2±6.3%). |
| [IC 50]
P2Y2 Receptor | [References]
[1] Ji Hun Choi, et al. Uridine Triphosphate Increases Proliferation of Human Cancerous Pancreatic Duct Epithelial Cells by Activating P2Y2 Receptor. Pancreas. 2013 May;42(4):680-6. DOI:10.1097/MPA.0b013e318271bb4b
[2] Edith Hochhauser, et al. P2Y2 Receptor Agonist With Enhanced Stability Protects the Heart From Ischemic Damage in Vitro and in Vivo. Purinergic Signal. 2013 Dec;9(4):633-42. DOI:10.1007/s11302-013-9374-3 |
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