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2568273-79-8

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2568273-79-8 Structure

2568273-79-8 Structure

Identification	Back Directory
[Name] PROTAC SMARCA2/4-degrader-32
[CAS] 2568273-79-8
[Synonyms] PROTAC SMARCA2/4-degrader-32
[Molecular Formula] C54H69N13O5S
[MOL File] 2568273-79-8.mol
[Molecular Weight] 1012.28

Chemical Properties	Back Directory
[density ] 1.314±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
[pka] 6.274±0.30(predicted)

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[Uses] PROTAC SMARCA2/4-degrader-32 (compound I-446) is a PROTAC degrader targeting SMARCA2 and SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC50s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment[1].
[References] [1] Preparation of heterocyclic compounds as SMARCA degraders and uses thereof. World Intellectual Property Organization, WO2020251971 A1 2020-12-17.

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Company Name:	TargetMol Chemicals Inc.
Tel:	15002134094
Website:	https://www.targetmol.cn/

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