| Identification | Back Directory | [Name]
PROTAC SMARCA2 degrader-16 | [CAS]
2568276-37-7 | [Synonyms]
PROTAC SMARCA2 degrader-16
2,6-Piperidinedione, 3-[5-[3-[4-[4-[3-[3-amino-6-(2-hydroxyphenyl)-4-pyridazinyl]-3,8-diazabicyclo[3.2.1]oct-8-yl]-2-pyrimidinyl]-1-piperidinyl]propyl]-2,3-dihydro-3-methyl-2-oxo-1H-benzimidazol-1-yl]- | [Molecular Formula]
C41H47N11O4 | [MOL File]
2568276-37-7.mol | [Molecular Weight]
757.88 |
| Hazard Information | Back Directory | [Uses]
PROTAC SMARCA2 degrader-16 (compound I-278) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment[1]. | [References]
[1] Preparation of heterocyclic compounds as SMARCA degraders and uses thereof. World Intellectual Property Organization, WO2020251971 A1 2020-12-17. |
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