| Identification | Back Directory | [Name]
PROTAC SMARCA2 degrader-14 | [CAS]
2568276-73-1 | [Synonyms]
PROTAC SMARCA2 degrader-14
1H-Isoindole-1,3(2H)-dione, 5-[[4-[4-[4-[3-amino-6-(2-hydroxyphenyl)-4-pyridazinyl]-1H-pyrazol-1-yl]-1-piperidinyl]cyclohexyl]amino]-2-(2,6-dioxo-3-piperidinyl)- | [Molecular Formula]
C37H39N9O5 | [MOL File]
2568276-73-1.mol | [Molecular Weight]
689.76 |
| Chemical Properties | Back Directory | [Boiling point ]
974.856±65.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.576±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
8.382±0.35(predicted) |
| Hazard Information | Back Directory | [Uses]
SMARCA2 degrader-3 (compound I-323) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment[1]. | [References]
[1] Preparation of heterocyclic compounds as SMARCA degraders and uses thereof. World Intellectual Property Organization, WO2020251971 A1 2020-12-17. |
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