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2568277-42-7

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2568277-42-7 Structure

2568277-42-7 Structure

Identification	Back Directory
[Name] PROTAC SMARCA2 degrader-12
[CAS] 2568277-42-7
[Synonyms] PROTAC SMARCA2 degrader-12
[Molecular Formula] C49H57N11O5S
[MOL File] 2568277-42-7.mol
[Molecular Weight] 912.12

Chemical Properties	Back Directory
[density ] 1.343±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
[pka] 6.274±0.30(predicted)

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[Uses] SMARCA2 degrader-13 (compound I-406) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment[1].
[References] [1] Preparation of heterocyclic compounds as SMARCA degraders and uses thereof. World Intellectual Property Organization, WO2020251971 A1 2020-12-17.

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