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2568277-48-3

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2568277-48-3 Structure

2568277-48-3 Structure

Identification	Back Directory
[Name] PROTAC SMARCA2/4-degrader-22
[CAS] 2568277-48-3
[Synonyms] PROTAC SMARCA2/4-degrader-22
[Molecular Formula] C51H61N11O6S
[MOL File] 2568277-48-3.mol
[Molecular Weight] 956.17

Chemical Properties	Back Directory
[density ] 1.39±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka] 6.27±0.30(predicted)

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[Uses] SMARCA2 degrader-14 (compound I-408) is a PROTAC degrader targeting SMARCA2 and SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC50s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment[1].
[References] [1] Preparation of heterocyclic compounds as SMARCA degraders and uses thereof. World Intellectual Property Organization, WO2020251971 A1 2020-12-17.

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Company Name:	TargetMol Chemicals Inc.
Tel:	15002134094
Website:	https://www.targetmol.cn/

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