| Identification | Back Directory | [Name]
1H-Imidazole-1-ethanol, 2-(ethoxymethyl)-4-iodo-α,α-dimethyl-5-phenyl- | [CAS]
2573912-32-8 | [Synonyms]
CU-CPD107
1H-Imidazole-1-ethanol, 2-(ethoxymethyl)-4-iodo-α,α-dimethyl-5-phenyl- | [Molecular Formula]
C16H21IN2O2 | [MOL File]
2573912-32-8.mol | [Molecular Weight]
400.26 |
| Chemical Properties | Back Directory | [Boiling point ]
513.0±50.0 °C(Predicted) | [density ]
1.46±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 80 mg/mL (199.87 mM);Ethanol: 80 mg/mL (199.87 mM) | [form ]
powder | [pka]
14.60±0.29(Predicted) | [color ]
white to beige | [Water Solubility ]
Water: Insoluble | [InChI]
1S/C16H21IN2O2/c1-4-21-10-13-18-15(17)14(12-8-6-5-7-9-12)19(13)11-16(2,3)20/h5-9,20H,4,10-11H2,1-3H3 | [InChIKey]
XCYMSVIYUJTAPJ-UHFFFAOYSA-N | [SMILES]
CC(C)(O)CN(C(COCC)=N1)C(C2=CC=CC=C2)=C1I |
| Hazard Information | Back Directory | [Uses]
CU-CPD107 is a potent, selective toll-like receptor 8 (TLR 8) agonist. CU-CPD107 inhibits TLR8 signaling. CU-CPD107 converts to synergistic agonist activities in the presence of ssRNA and induces TLR8 signaling. CU-CPD107 inhibits proinflammatory factor expression and avoids immune responses in the presence of ssRNA[1]. | [Biological Activity]
CU-CPD107 is a selective, dual-activity small-molecule which demonstrated differential activity against the TLR8 agonists and ssRNA ligands. In the presence of R848, CU-CPD107 acts as a TLR8 signaling inhibitor (IC50=13.7 μM). In the presence of ssRNA, CU-CPD107 shows synergistic agonist activities, while CU-CPD107 alone is unable to influence TLR8 signaling.
CU-CPD107, a tetrasubstituted imidazole, inhibits R848-induced TLR8 signaling and shows unexpected synergistic agonist activities in the presence of ssRNA, while CU-CPD107 alone is unable to influence TLR8 signaling.[1] | [References]
[1] Yang Y, et al. Nat Commun. 2021 Jul 16;12(1):4351. |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
Biorbyt Ltd.
|
| Tel: |
+44 (0)1223 859 353 |
| Website: |
http://www.biorbyt.com |
|