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VD4162 (Compound 8b) is a macrocyclic inhibitor of serine proteases. VD4162 can significantly improve potency for all four target enzymes TMPRSS2 (IC50 = 3.7 nM), HGFA(IC50 = 3.3 nM), matriptase (IC50 = 2.9 nM), and hepsin (IC50 = 0.54 nM). VD4162 can be used for the research of cancer[1]. | [References]
[1] Damalanka VC, et al. Mechanism-Based Macrocyclic Inhibitors of Serine Proteases. J Med Chem. 2024 Mar 28;67(6):4833-4854. DOI:10.1021/acs.jmedchem.3c02388 |
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