| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
Soluble to 100 mM in DMSO and to 50 mM in ethanol | [form ]
powder | [color ]
white to beige | [Optical Rotation]
[α]/D -6 to -8°, c = 1 in methanol | [InChIKey]
HUCQUCITPHOUAC-DSSYAJFBSA-N | [SMILES]
O=C(O)/C=C/C(O)=O.CC(C)=CCCN(CC1)CCC1NC([C@](C2CCCC2)(O)C3=CC=CC=C3)=O |
| Hazard Information | Back Directory | [Uses]
J 104129 Fumarate is a novel muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors. | [Biochem/physiol Actions]
J104129 is a muscarinic M3 receptor antagonist greater than 100-fold selectivity for M3 over M2 receptors. Its Ki for M3 receptors = 4.2 nM compared to a Ki of 490 nM for M2 receptors. J-104129 showed potent bronchodilator activity in animal studies. | [IC 50]
mAChR3: 4.2 nM (Ki); mAChR2: 490 nM (Ki) | [storage]
Store at +4°C |
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