| Identification | Back Directory | [Name]
Methanesulfonamide, N-[3-[1-[(4-methylphenyl)methyl]-1H-benzimidazol-2-yl]phenyl]- | [CAS]
2579696-45-8 | [Synonyms]
Antimicrobial agent-1
Methanesulfonamide, N-[3-[1-[(4-methylphenyl)methyl]-1H-benzimidazol-2-yl]phenyl]- | [Molecular Formula]
C22H21N3O2S | [MOL File]
2579696-45-8.mol | [Molecular Weight]
391.49 |
| Hazard Information | Back Directory | [Uses]
Antimicrobial agent-1 (compound 6C) possesses potent activity against TolC mutant E. coli with an MIC value of 2 μg/mL. Antimicrobial agent-1 and Colistin exhibit synergistic activity against Gram-negative bacteria. Antimicrobial agent-1 has no cytotoxicity on mammalian cell lines, with MICs > 128?μg/mL in Caco-2 and Vero cell lines[1]. | [References]
[1] Dokla EME, et al. Development of benzimidazole-based derivatives as antimicrobial agents and their synergistic effect with colistin against gram-negative bacteria. Eur J Med Chem. 2020;186:111850. DOI:10.1016/j.ejmech.2019.111850 |
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