| Identification | Back Directory | [Name]
4H-1-Benzopyran-3-carboxylic acid, 2-amino-7-hydroxy-4-[4-[2-(4-morpholinyl)ethoxy]phenyl]-, methyl ester | [CAS]
2580941-14-4 | [Synonyms]
Estrogen receptor β antagonist 2
4H-1-Benzopyran-3-carboxylic acid, 2-amino-7-hydroxy-4-[4-[2-(4-morpholinyl)ethoxy]phenyl]-, methyl ester | [Molecular Formula]
C23H26N2O6 | [MOL File]
2580941-14-4.mol | [Molecular Weight]
426.46 |
| Chemical Properties | Back Directory | [Boiling point ]
622.9±55.0 °C(Predicted) | [density ]
1.294±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
9.24±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Estrogen receptor β antagonist 2 is a potent and selective estrogen receptor β (ERβ) antagonist with IC50s of 109.10, 0.63 μM for Erα and Erβ, respectively[1]. | [IC 50]
ERα: 109.10 μM (IC50); ERβ: 0.63 μM (IC50) | [References]
[1] Carr M, et al. Optimisation of estrogen receptor subtype-selectivity of a 4-Aryl-4H-chromene scaffold previously identified by virtual screening. Bioorg Med Chem. 2020 Mar 1;28(5):115261. DOI:10.1016/j.bmc.2019.115261 |
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