| Identification | Back Directory | [Name]
Phenol, 4-(dodecylamino)- | [CAS]
25848-37-7 | [Synonyms]
pDDAP
p-DDAP
p DDAP
p-Dodecylaminophenol
Phenol, 4-(dodecylamino)- | [Molecular Formula]
C18H31NO | [MDL Number]
MFCD28160722 | [MOL File]
25848-37-7.mol | [Molecular Weight]
277.44 |
| Hazard Information | Back Directory | [Description]
p-DDAP is an anti-invasive agent. It acts by significantly suppressing cell invasion, and the activity and mRNA expression of matrix metalloproteinase-9 (MMP-9). | [Uses]
4-(Dodecylamino)phenol (p-DDAP) is an anticancer agent. 4-(Dodecylamino)phenol has anti-tumor activity and can suppress proliferation, arrest the cell cycle and induce apoptotic cell death. 4-(Dodecylamino)phenol can be used for the research of cancer, such as prostate cancer[1][2]. | [in vivo]
4-(Dodecylamino)phenol (p-DDAP) (10, 15, 40 mg/kg; i.v., daily, for 2 weeks or i.p., single) exhibits excellent anticancer efficacy against hormonal independent prostate cancer in vivo[2]. | Animal Model: | Specific pathogen-free athymic BALB/c nu/nu nude mice (6
weeks of age, male)[2] | | Dosage: | 10, 15, 40 mg/kg | | Administration: | i.v., daily, for 2 weeks or i.p., single | | Result: | Suppressed tumor growth in PC-3-implanted mice in vivo. |
| [References]
[1] Noriko Takahashi, et al. The anti-tumor agent, p-DDAP potently suppresses proliferation through apoptosis in human neuroblastoma NB-39-nu cells. Cancer Lett DOI:10.1016/j.canlet.2010.05.018 |
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