| Identification | Back Directory | [Name]
cephalochromin | [CAS]
25908-26-3 | [Synonyms]
SCH-45752
cephalochromin
2,2',3,3'-Tetrahydro-5,5',6,6',8,8'-hexahydroxy-2,2'-dimethyl-9,9'-bi[4H-naphtho[2,3-b]pyran]-4,4'-dione
[9,9'-Bi-4H-naphtho[2,3-b]pyran]-4,4'-dione, 2,2',3,3'-tetrahydro-5,5',6,6',8,8'-hexahydroxy-2,2'-dimethyl-, (2R,2'R,9S)- | [Molecular Formula]
C28H22O10 | [MOL File]
25908-26-3.mol | [Molecular Weight]
518.47 |
| Hazard Information | Back Directory | [Uses]
Cephalochromin is an antibiotic and an inhibitor for bacterial fatty acid synthase (FabI). Cephalochromin inhibits FabI of Staphylococcus aureus and Escherichia coli with IC50 of 1.9 and 1.8 μM. Cephalochromin inhibits gram-positive methicillin-resistant S. aureus (MRSA) and quinolone-resistant S. aureus (QRSA), with MIC of 2-8 μg/mL[1]. | [Definition]
ChEBI: Cephalochromin is an organooxygen compound and an organic heterotricyclic compound. | [storage]
+4°C | [References]
[1] Zheng CJ, et al., Cephalochromin, a FabI-directed antibacterial of microbial origin. Biochem Biophys Res Commun. 2007 Nov 3;362(4):1107-12. DOI:10.1016/j.bbrc.2007.08.144 |
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