| Identification | Back Directory | [Name]
4H-Thieno[3,2-c][1]benzothiopyran-2-carboxamide, 7-[2-(4-methoxybenzoyl)phenyl]-N-[(4-methylphenyl)methyl]-, 5,5-dioxide | [CAS]
2595314-46-6 | [Synonyms]
7-[2-(4-methoxybenzoyl)phenyl]-N-[(4-methylphenyl)methyl]-5,5-dioxo-4H-thieno[3,2-c]thiochromene-2-carboxamide
4H-Thieno[3,2-c][1]benzothiopyran-2-carboxamide, 7-[2-(4-methoxybenzoyl)phenyl]-N-[(4-methylphenyl)methyl]-, 5,5-dioxide | [Molecular Formula]
C34H27NO5S2 | [MOL File]
2595314-46-6.mol | [Molecular Weight]
593.71 |
| Chemical Properties | Back Directory | [Boiling point ]
907.9±65.0 °C(Predicted) | [density ]
1.328±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 100 mg/mL (168.43 mM; Need ultrasonic) | [form ]
Solid | [pka]
12.62±0.20(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
WEHI-9625 is a tricyclic sulfone, first-in-class inhibitor of apoptosis with an EC50 of 69 nM. WEHI-9625 binds to VDAC2 and promotes its ability to inhibit apoptosis driven by mouse BAK. WEHI-9625 is completely inactive against both human BAK and the closely related apoptosis effector BAX[1]. | [Biological Activity]
WEHI-9625 is a tricyclic sulfone, first-in-class inhibitor of apoptosis with an EC50 of 69 nM. WEHI-9625 binds to VDAC2 and promotes its ability to inhibit apoptosis driven by mouse BAK. WEHI-9625 is completely inactive against both human BAK and the closely related apoptosis effector BAX[1].
WEHI-9625 (0-10 μM; Mcl1-/-Bax-/- MEFs cells) treatment could prevent cell death mediated by BAK and potently inhibits BIM BH3-induced loss of mitochondrial membrane potential in Bax-/-, but not Bak-/-, cells[1].
WEHI-9625 demonstrates that blocking apoptosis at an early stage was both advantageous and pharmacologically tractable[1]. | [in vivo]
WEHI-9625 demonstrates that blocking apoptosis at an early stage was both advantageous and pharmacologically tractable[1]. | [IC 50]
Bak; Bax | [References]
[1]. van Delft MF, et al. A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis. Nat Chem Biol. 2019 Oct 7. |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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