| Identification | Back Directory | [Name]
3-(4-(5-Aminopentyl)-1-oxoisoindolin-2-yl) piperidine-2,6-dione hydrochloride | [CAS]
2595367-27-2 | [Synonyms]
3-(4-(5-Aminopentyl)-1-oxoisoindolin-2-yl) piperidine-2,6-dione hydrochloride | [Molecular Formula]
C18H23N3O3.ClH | [MOL File]
2595367-27-2.mol | [Molecular Weight]
365.86 |
| Hazard Information | Back Directory | [Uses]
Lenalidomide-C5-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-NH2 can be connected to the ligand for protein by a linker to form PROTACs, such as MDM2 PROTAC degrader[1][2]. | [IC 50]
Cereblon | [References]
[1] Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481. DOI:10.1021/acs.jmedchem.6b01816
[2] Yangbing Li, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression. J Med Chem. 2019 Jan 24;62(2):448-466. DOI:10.1021/acs.jmedchem.8b00909 |
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