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FFN511 (hydrochloride) is a potent fluorescent false neurotransmitters (FFNs) that targets neuronal vesicular monoamine transporter 2 (VMA T2). FFN511 (hydrochloride) inhibits serotonin binding to VMA T2-containing membranes with an IC50 of 1 μM. FFN511 (hydrochloride) directly images the dynamics of release during exocytosis, can be used to label dopamine terminals in live cortical-striatalacute slices[1][2]. | [References]
[1] Gubernator NG, et al. Fluorescent false neurotransmitters visualize dopamine release from individual presynaptic terminals. Science. 2009 Jun 12;324(5933):1441-4. DOI:10.1126/science.1172278
[2] Keighron JD, et al. Analytical tools to monitor exocytosis: a focus on new fluorescent probes and methods. Analyst. 2012 Apr 21;137(8):1755-63. DOI:10.1039/c2an15901e |
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