| Identification | Back Directory | [Name]
2-Pyridinecarboxylic acid, 6-(4-ethoxyphenyl)-4-methoxy-, 1-methylethyl ester | [CAS]
2598242-66-9 | [Synonyms]
2-Pyridinecarboxylic acid, 6-(4-ethoxyphenyl)-4-methoxy-, 1-methylethyl ester | [Molecular Formula]
C18H21NO4 | [MOL File]
2598242-66-9.mol | [Molecular Weight]
315.36 |
| Chemical Properties | Back Directory | [Boiling point ]
464.9±45.0 °C(Predicted) | [density ]
1.111±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: insol,DMSO: 3 mg/ml,Ethanol: insol,PBS (pH 7.2): insol | [form ]
A crystalline solid | [pka]
2.93±0.26(Predicted) | [color ]
Off-white to light yellow | [InChI]
1S/C18H21NO4/c1-5-22-14-8-6-13(7-9-14)16-10-15(21-4)11-17(19-16)18(20)23-12(2)3/h6-12H,5H2,1-4H3 | [InChIKey]
VYEIBLWRGBQRPI-UHFFFAOYSA-N | [SMILES]
O=C(C1=CC(OC)=CC(C2=CC=C(OCC)C=C2)=N1)OC(C)C |
| Hazard Information | Back Directory | [Uses]
NG-497 is a selective human adipose triglyceride lipase (ATGL) inhibitor that targets the enzymatically active patatin-like domain of human ATGL. NG-497 has potential value for tumor research[1]. | [Biological Activity]
NG-497 is a non-cytotoxicsubstrate-competitivereversible and highly selective human/primate adipose triglyceride lipase (ATGL; IPLA2-zeta; PNPLA2) inhibitor (IC50 = 1 μMKi = 0.5 μM) with little activity toward related human lipid hydrolases or ATGL orthologues from other species (<20% inhibition of mouseratgoatpigdogmarmoset ATGL at 50 μM). NG-497 abolishes hormone-induced lipolysis in human adipocytes (IC50 = 1.5 and 0.5 μM against 1 μM isoproterenol-induced total or hormonesensitive lipase (HSL)-independent FA release in Simpson-Golabi-Behmel syndrome adipocytes)but not in HepG2 th at lacks ATGL hydrolase activity. | [References]
[1] Gernot F Grabner, et al. Small-Molecule Inhibitors Targeting Lipolysis in Human Adipocytes. J Am Chem Soc. 2022 Apr 13;144(14):6237-6250. DOI:10.1021/jacs.1c10836 |
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| Company Name: |
InvivoChem
|
| Telephone: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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