2599838-15-8

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2599838-15-8 Structure

Chemical Properties	Back Directory
[density ] 2.08±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka] 9.46±0.20(predicted)

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[Uses] HDAC/CK2-IN-1 (compound 38) is a HDAC1 (IC50 = 1.46 μM), HDAC6 (IC50 = 0.66 μM), and CK2 (IC50 = 3.67 μM) inhibitor. HDAC/CK2-IN-1 exhibits promising antproliferative activity against Jurkat, MCF-7, HCT-116, and HL-60 cell lines[1].
[IC 50] HDAC1: 1.46 μM (IC₅₀); HDAC6: 0.66 μM (IC₅₀); CK2: 3.67 μM (IC₅₀)
[References] [1] Al-Qadhi MA, et al. Recent Advances in the Discovery of CK2 Inhibitors. ACS Omega. 2024 May 3;9(19):20702-20719. DOI:10.1021/acsomega.3c10478

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