| Identification | Back Directory | [Name]
1,2-Benzisoselenazol-3(2H)-one, 2-(4-ethylphenyl)- | [CAS]
2605897-57-0 | [Synonyms]
1,2-Benzisoselenazol-3(2H)-one, 2-(4-ethylphenyl)- | [Molecular Formula]
C15H13NOSe | [MOL File]
2605897-57-0.mol | [Molecular Weight]
302.23 |
| Hazard Information | Back Directory | [Description]
FBA inhibitor 2a11 has potent inhibitory activity against resistant fungi, establishing a structural foundation and providing a promising strategy for the design of potent antifungal drugs. | [Uses]
FBA-IN-1 (compound 2a11) is a first-in-class, covalent and allosteric inhibitor of fructose-1,6-bisphosphate aldolase from Candida albicans (CaFBA). FBA-IN-1 inhibits the growth of Azole-resistant strains 103 with the MIC80 of 1 μg/mL[1]. | [References]
[1] Wuqiang Wen, et al. Structure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of Candidiasis. J Med Chem. 2022 Feb 10;65(3):2656-2674. DOI:10.1021/acs.jmedchem.1c02102 |
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