| Identification | Back Directory | [Name]
1H-1,2,4-Triazol-5-amine, 3-[[(4-chlorophenyl)methyl]thio]-1-[(2,3-dihydro-5-benzofuranyl)sulfonyl]- | [CAS]
2609594-35-4 | [Synonyms]
PAL-4
1H-1,2,4-Triazol-5-amine, 3-[[(4-chlorophenyl)methyl]thio]-1-[(2,3-dihydro-5-benzofuranyl)sulfonyl]-
PAL-4,inhibit,PAL 4,LYPLAL1,Lysophospholipase-like 1,Metabolic disorders,Inhibitor,PAL4,1H1,2,4Triazol5amine, 3[[(4chlorophenyl)methyl]thio]1[(2,3dihydro5benzofuranyl)sulfonyl],1H 1,2,4 Triazol 5 amine, 3 [[(4 chlorophenyl)methyl]thio] 1 [(2,3 dihydro 5 benzofuranyl)sulfonyl | [Molecular Formula]
C17H15ClN4O3S2 | [MOL File]
2609594-35-4.mol | [Molecular Weight]
422.91 |
| Hazard Information | Back Directory | [Uses]
PAL-4 (compound 4) is a potent, selective and reversible Lysophospholipase-like 1 (LYPLAL1) activator with EC50 value of 0.39 μM and 0.49 μM for mice LYPLAL1 and huamn LYPLAL1, respectively. PAL-4 can be used for researching metabolic disorders[1]. | [References]
[1] Kok BP, et al. Discovery of small-molecule enzyme activators by activity-based protein profiling. Nat Chem Biol. 2020;16(9):997-1005. DOI:10.1038/s41589-020-0555-4 |
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