| Identification | Back Directory | [Name]
(9S)-9-Amino-9-deoxoerythromycin | [CAS]
26116-56-3 | [Synonyms]
LY 024410
BRL 42852ER
Brn 4241492
Erythromycylamine
Erythromycilamine
9-Epierythromycylamine
Epierythromycyl-A-amine
9-(S)-AMINOERYTHROMYCIN
(9S)-erythromycyclamine
Dirithromycin impurity A
(9S)-Erythromycylamine A
Dirithromycin EP impurity A
(9s)-9-aMino-9-deoxoeryhtroMycin
(9S)-9-AMiNA-9-deoxoerythroMycin
(9S)-9-Amino-9-deoxoerythromycin
(9S)-9-amino-9-deoxyerythromycin
(9S)-9-Deoxy-9-aminoerythromycin A
Erythromycin, 9-amino-9-deoxo-, (9S)-
9-Amino-9-deoxo-erythromycin, stereoisomer
Erythromycin, 9-amino-9-deoxo-, (9S)- (9ci)
Erythromycin, 9-amino-9-deoxo-, stereoisomer
9(S) ErythroMycylaMin A, BRL 42852ER, LY 024410
Erythromycylamine (Dirithromycin EP Impurity A)
Dirithromycin EP Impurity A (Erythromycylamine)
9-(S)-ERYTHROMYCYLAMINE:9-AMINO-9-DEOXO-ERYTHROMYCIN
Dirithromycin Impurity 1(Dirithromycin EP Impurity A)
Dirithromycin Impurit Ⅰ: (9S)-9-Amino-9-deoxoerythromycin
(9S)-9-Amino-9-deoxoerythromycin (9S)-9-Amino-9-deoxoerythromycin
Dirithromycin EP Impurity A/Erythromycylamine/(3R,4S,5S,6R,7R,9R,10S,11S,12R,13S,14R)-10-amino-6-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-ethyl-7,12,13-trihydroxy-4-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimeth | [EINECS(EC#)]
406-790-7 | [Molecular Formula]
C37H70N2O12 | [MDL Number]
MFCD00872156 | [MOL File]
26116-56-3.mol | [Molecular Weight]
734.96 |
| Chemical Properties | Back Directory | [Melting point ]
123-127°C | [Boiling point ]
810.3±65.0 °C(Predicted) | [density ]
1.19±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | [solubility ]
DMF: 15 mg/ml; DMSO: 15 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml | [form ]
A solid | [pka]
13.41±0.70(Predicted) | [color ]
White to off-white | [Optical Rotation]
Consistent with structure | [InChIKey]
XCLJRCAJSCMIND-FLSDEJNQNA-N |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,N | [Risk Statements ]
41-50/53 | [Safety Statements ]
26-39-60-61 | [REACH Registrations]
Inactive | [Toxicity]
mouse,LD50,intraperitoneal,120mg/kg (120mg/kg),European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 13, Pg. 83, 1978. |
| Hazard Information | Back Directory | [Chemical Properties]
(9S)-9-Amino-9-deoxoerythromycin is White Solid
| [Uses]
(9S)-9-Amino-9-deoxoerythromycin is a semi-synthetic analogue of erythromycin prepared by reduction of erythromycin oxime. (9S)-9-Amino-9-deoxoerythromycin is a potent antibiotic, however the introduction of the amino- moiety increases the compound’s polarity and is disadvantageous for in vivo use. This limitation was overcome by the synthesis of dirithromycin, a Schiff base pro-drug that dissociates in vivo to erythromycylamine.
| [Uses]
(9S)-9-Amino-9-deoxoerythromycin is a metabolite of Dirithromycin; an antibiotic
| [Uses]
Erythromycylamine is a semi-synthetic analogue of erythromycin prepared by reduction of erythromycin oxime. Erythromycylamine is a potent antibiotic, however the introduction of the amino- moiety increases the compound’s polarity and is disadvantageous for in vivo use. This limitation was overcome by the synthesis of dirithromycin, a Schiff base pro-drug that dissociates in vivo to erythromycylamine. | [Definition]
ChEBI: A macrolide antibiotic that is erythromycin A in which the ketone group has been converted to the corresponding imine and then reduced to give the corresponding amino compound (the 9S diastereoisomer). |
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