| Identification | Back Directory | [Name]
2-(2,6-dioxopiperidin-3-yl)-6-methyl-6,7-dihydropyrrolo[3,4-f]isoindole-1,3(2H,5H)-dione | [CAS]
2616540-84-0 | [Synonyms]
2-(2,6-dioxopiperidin-3-yl)-6-methyl-6,7-dihydropyrrolo[3,4-f]isoindole-1,3(2H,5H)-dione |
| Hazard Information | Back Directory | [Uses]
Thalidomide-methylpyrrolidine is a ligand for E3 ubiquitinase. Thalidomide-methylpyrrolidine can be used to synthesize CW-3308 (HY-159579)[1]. | [IC 50]
Cereblon | [References]
[1] Wang C, et al. Discovery of CW-3308 as a Potent, Selective, and Orally Efficacious PROTAC Degrader of BRD9. J Med Chem. 2024 Aug 22;67(16):14125-14154. DOI:10.1021/acs.jmedchem.4c00971 |
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