| Identification | Back Directory | [Name]
2-Propen-1-one, 3-[(1R,4R)-5-(4-fluorophenyl)-2,5-diazabicyclo[2.2.1]hept-2-yl]-1-phenyl-, (2E)- | [CAS]
2616813-99-9 | [Synonyms]
BRG1-IN-1
2-Propen-1-one, 3-[(1R,4R)-5-(4-fluorophenyl)-2,5-diazabicyclo[2.2.1]hept-2-yl]-1-phenyl-, (2E)- | [Molecular Formula]
C20H19FN2O | [MOL File]
2616813-99-9.mol | [Molecular Weight]
322.38 |
| Hazard Information | Back Directory | [Uses]
BRG1-IN-1 (Compound 11d) is a potent inhibitor of SMARCA4/BRG1. BRG1-IN-1 shows better efficacy than PFI-3 in sensitizing GBM cells to the antiproliferative and cell death inducing effects of Temozolomide in vitro. BRG1-IN-1 enhances the inhibitor effect of Temozolomide on the growth of subcutaneous GBM tumors[1]. | [References]
[1] He Y, et al. Novel structural-related analogs of PFI-3 (SRAPs) that target the BRG1 catalytic subunit of the SWI/SNF complex increase the activity of temozolomide in glioblastoma cells. Bioorg Med Chem. 2022 Jan 1;53:116533. DOI:10.1016/j.bmc.2021.116533 |
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