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2617376-08-4

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2617376-08-4 Structure

2617376-08-4 Structure
IdentificationBack Directory
[Name]

Benzamide, 2-[[3-(acetylamino)-1H-indazol-6-yl]thio]-N-methyl-
[CAS]

2617376-08-4
[Synonyms]

Benzamide, 2-[[3-(acetylamino)-1H-indazol-6-yl]thio]-N-methyl-
[Molecular Formula]

C17H16N4O2S
[MOL File]

2617376-08-4.mol
[Molecular Weight]

340.4
Chemical PropertiesBack Directory
[Boiling point ]

700.8±50.0 °C(predicted)
[density ]

1.39±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka]

11.84±0.40(predicted)
Hazard InformationBack Directory
[Uses]

CPD-002 is an inhibitor for vascular endothelial growth factor receptor 2 (VEGFR 2), that inhibits angiogenesis through inhibition of VEGFR2/PI3K/AKT signaling pathway. CPD-002 exhibits anti-inflammatory activity and attenuates rheumatoid arthritis[1].
[in vivo]

CPD-002 (15-60 mg/kg, i.p., once daily for 14 days) exhibits anti-arthritic and anti-angiogenic effects in adjuvant-induced arthritisrats rats model[1].

Animal Model:adjuvant-induced arthritis (AIA) Sprague Dawley rats models[1]
Dosage:15-60 mg/kg
Administration:i.p., once daily for 14 days
Result:Ameliorated paw swelling, joint damage, and synovial angiogenesis.
[References]

[1] Jiang F, et al., CPD-002, a novel VEGFR2 inhibitor, relieves rheumatoid arthritis by reducing angiogenesis through the suppression of the VEGFR2/PI3K/AKT signaling pathway. Int Immunopharmacol. 2024 Apr 20;131:111850. DOI:10.1016/j.intimp.2024.111850
2617376-08-4 suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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