| Identification | Back Directory | [Name]
5-HT4 antagonist 1 | [CAS]
261766-73-8 | [Synonyms]
5-HT4 antagonist 1
1,4-Benzodioxin-5-carboxamide, 2,3-dihydro-N-[[1-[3-[(4-methyl-1-piperazinyl)sulfonyl]propyl]-4-piperidinyl]methyl]- | [Molecular Formula]
C23H36N4O5S | [MDL Number]
MFCD30533305 | [MOL File]
261766-73-8.mol | [Molecular Weight]
480.62 |
| Chemical Properties | Back Directory | [density ]
1.31±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
14.39±0.20(Predicted) | [color ]
Light brown to brown |
| Hazard Information | Back Directory | [Uses]
5-HT4 antagonist 1 is a 5-HT4 receptor antagonist with a pKi of 9.6. | [in vivo]
5-HT4 antagonist 1 (compound 6b) demonstrates good exposure and prolongs t1/2 in other species, including the mouse (t1/2 7 h), rat (t1/2 12 h) and mini-pig (t1/2 21 h). In Phase I clinical trial, it is found that 5-HT4 antagonist 1 has good oral bioavailability with a steady state plasma t1/2 of >100 h[1]. | [IC 50]
5-HT4 Receptor: 9.6 (pKi) | [storage]
Store at -20°C | [References]
[1] Clark RD, et al. Identification of a 5-HT4 receptor antagonist clinical candidate through side-chain modification. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1697-700. DOI:10.1016/j.bmcl.2005.01.039 |
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