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DHODH-IN-25 (Compound 25) is an orally active dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 value of 5.4 nM for human DHODH. DHODH-IN-25 can be used for the study of acute myeloid leukemia (AML)[1]. | [References]
[1] DeRatt, Lindsey G., et al. "Discovery of Alternative Binding Poses through Fragment-Based Identification of DHODH Inhibitors." ACS Medicinal Chemistry Letters (2024). |
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