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2619854-01-0

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2619854-01-0 Structure

2619854-01-0 Structure
IdentificationBack Directory
[Name]

INDEX NAME NOT YET ASSIGNED
[CAS]

2619854-01-0
[Synonyms]

c[Arg-Arg-Arg-Arg-Nal-Nal-Nal]
cyclo(Arg-Arg-Arg-Arg-Nal-Nal-Nal)
[Molecular Formula]

C63H81N19O7
[MOL File]

2619854-01-0.mol
[Molecular Weight]

1216.47
Chemical PropertiesBack Directory
[density ]

1.43±0.1 g/cm3(Predicted)
[pka]

12.87±0.70(Predicted)
[Sequence]

c[Arg-Arg-Arg-Arg-{D-2-Nal}-{D-2-Nal}-{D-2-Nal}]
Hazard InformationBack Directory
[Uses]

c[Arg-Arg-Arg-Arg-Nal-Nal-Nal] (Compound 9C) shows broad-spectrum activity against drug-resistant Gram-positive and Gram-negative bacteria, with MICs of 3.1, 3,1, 12.5, and 25 μg/mL for MRSA (ATCC BAA-1556), S. aureus (ATCC 29213), P. aeruginosa (ATCC 27883), and E. coli (ATCC 25922), respectively[1].
[References]

[1] Sandeep Lohan, et al. Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties. J Med Chem. 2022 Jan 13;65(1):665-687. DOI:10.1021/acs.jmedchem.1c01782
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