| Identification | Back Directory | [Name]
Nintedanib impurity E | [CAS]
262366-32-5 | [Synonyms]
Intedanib Impurity E
Nintedanib impurity E
Desmethoxycarbonyl Nintedanib
1-Piperazineacetamide, N-[4-[[(Z)-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)phenylmethyl]amino]phenyl]-N,4-dimethyl-
Nintedanib impurity 23/N-[4-[[(Z)-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)phenylmethyl]amino]phenyl]-N,4-dimethyl-1-piperazineacetamide | [Molecular Formula]
C29H31N5O2 | [MOL File]
262366-32-5.mol | [Molecular Weight]
481.59 |
| Hazard Information | Back Directory | [Uses]
N-[4-[[(Z)-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)phenylmethyl]amino]phenyl]-N,4-dimethyl-1-piperazineacetamide was used in the study to discover a potent inhibitor of MELK that inhibits expression of the anti-apoptotic protein Mcl-1 and TNBC cell growth. N-[4-[[(Z)-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)phenylmethyl]amino]phenyl]-N,4-dimethyl-1-piperazineacetamide is an impurity of Intedanib (I666650), which is an antitumor agent. | [Synthesis]
1)(Z)-3-{1-[4-(N-(4-benzylpiperazinylmethylcarbonyl)-N-methyl-amino)-phenylamino]-1-phenyl-methylene}-2-dihydroindolone
Prepared from 1-acetyl-3-(1-ethoxy-1-phenyl-methylene)-2-dihydroindolone and 4-[N-(4-benzylpiperazinylmethyl-carbonyl)-N-met |
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