| Hazard Information | Back Directory | [Uses]
Pomalidomide 4'-PEG6-azide (compound 33e) is the E3 ligase ligand-linker conjugate used in the recruitment of CRBN protein. Pomalidomide 4'-alkylC3-acid can be used to synthesize PROTACs[1]. | [Biological Activity]
Pomalidomide 4'-PEG6-azide is a functionalized cereblon ligand for PROTAC? research and development; incorporates an E3 ligase ligand plus a PEG6 linker with terminal azide ready for conjugation to a target protein ligand. | [IC 50]
Cereblon | [storage]
Store at -20°C | [References]
[1] Lailiang Qu, et al. Discovery of PT-65 as a highly potent and selective Proteolysis-targeting chimera degrader of GSK3 for treating Alzheimer's disease. Eur J Med Chem. 2021 Dec 15:226:113889. DOI:10.1016/j.ejmech.2021.113889 |
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