| Identification | Back Directory | [Name]
1H-Indole, 3-[1-(2-chlorophenyl)-2-nitroethyl]-2-phenyl- | [CAS]
2633686-36-7 | [Synonyms]
CB1R Allosteric modulator 3
1H-Indole, 3-[1-(2-chlorophenyl)-2-nitroethyl]-2-phenyl- | [Molecular Formula]
C22H17ClN2O2 | [MOL File]
2633686-36-7.mol | [Molecular Weight]
376.84 |
| Chemical Properties | Back Directory | [Boiling point ]
604.7±55.0 °C(Predicted) | [density ]
1.306±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
7.57±0.18(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
CB1R Allosteric modulator 3 is a CB1R positive allosteric modulator. CB1R Allosteric modulator 3 has potent inhibition of cAMP and β-Arrestin with EC50 values of 0.018 μM and 1.241 μM, respectively[1]. | [IC 50]
CB1 | [References]
[1] Peter C Schaffer, et al. Focused structure-activity relationship profiling around the 2-phenylindole scaffold of a cannabinoid type-1 receptor agonist-positive allosteric modulator: site-III aromatic-ring congeners with enhanced activity and solubility. Bioorg Med Chem. 2020 Nov 1;28(21):115727. DOI:10.1016/j.bmc.2020.115727 |
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