| Identification | Back Directory | [Name]
(±)12,13-DiHOME | [CAS]
263399-35-5 | [Synonyms]
(±)12,13-DiHOME
9-Octadecenoic acid, 12,13-dihydroxy-, (9Z)- | [Molecular Formula]
C18H34O4 | [MDL Number]
MFCD12912337 | [MOL File]
263399-35-5.mol | [Molecular Weight]
314.46 |
| Chemical Properties | Back Directory | [Boiling point ]
476.0±30.0 °C(Predicted) | [density ]
1.015±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml,PBS (pH 7.2): 10 μ g/ml | [form ]
Liquid | [pka]
4.78±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
(±)?-12,?13-?DIHOME is an exercise induced lipokine which has been shown to induce skeletal muscle fatty acid uptake. May be used in the treatment of neuropathic pain. | [Definition]
ChEBI: 12,13-DiHOME is a DiHOME obtained by formal dihydroxylation of the 12,13-double bond of octadeca-9,12-dienoic acid (the 9Z-geoisomer). It is a conjugate acid of a 12,13-DiHOME(1-). | [in vivo]
12,13-DiHOME (1 μg/kg; retro-orbitally injection; once daily for 2 weeks) acutely decreases levels of serum triglycerides in mice with high-fat diet model, and increases BAT uptake to defend cold[1].
| Animal Model: | Mice fed a high-fat diet[1] | | Dosage: | 1 μg/kg | | Administration: | Retro-orbitally injection; once daily for 2 weeks | | Result: | Displayed no effects on body weight, glucose tolerance or circulating nonesterified FA.
Increased BAT-specific lipid uptake and improved oral lipid tolerance.
Increased radiolabeled FA uptake (Fig. 3f) and glucose uptake. |
| Animal Model: | To explore the biosynthesis of (±)12, 13-dihome in mice in vivo[1] | | Dosage: | | | Administration: | 7-d cold challenge in mice: mice treated with norepinephrine (NE) for 30 min and exposed to 4°C-cold for 1 h | | Result: | Result: Increased in the circulation of male mice exposed to cold, but not female mice. And also, the enzymes producing 12,13-diHOME were uniquely induced in BAT by cold stimulation. |
| [storage]
Store at -20°C |
|
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Alfa Chemistry
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1-516-6625404 |
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https://www.alfa-chemistry.com |
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amyjet
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http://www.amyjet.com/ |
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