| Identification | Back Directory | [Name]
Apigenin-D5 | [CAS]
263711-74-6 | [Synonyms]
Apigenin-D5
Apigenin-d5 (Major)
Pelargidenon 1449-d5
[3,6,8,35d5]-Apigenin
4',5,7-Trihydroxyflavone-d5
5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one-d5 | [Molecular Formula]
C15H5D5O5 | [MDL Number]
MFCD09839941 | [MOL File]
263711-74-6.mol |
| Chemical Properties | Back Directory | [Appearance]
Pale Yellow Crystalline Solid | [Melting point ]
345-350°C | [storage temp. ]
-20°C Freezer | [solubility ]
DMSO (Slightly), Ethanol (Slightly, Heated), Methanol (Slightly) | [form ]
Solid | [color ]
Pale Yellow to Yellow |
| Hazard Information | Back Directory | [Chemical Properties]
Pale Yellow Crystalline Solid | [Uses]
The labelled aglucon of apiin and of apigenin-7-glucoside | [Description]
Apigenin-d5 is an internal standard for the quantificaiton of apigenin by GC- or LC-MS. Apigenin is a flavonoid compound found in many fruits and vegetables that selectively inhibits casein kinase 2 (CK2). Apigenin inhibits CK2 activity in the renal cortex with an IC50 value of 30 μM to improve renal function in a rat model of glomerulonephritis. CK2 inhibition by 20 μM apigenin decreases the degradation of IκBα and down-regulates NF-κB levels in WEHI-231 cells. Apigenin, at 5 μM, is a potent inhibitor of the synthesis of the inflammatory mediators nitric oxide and prostaglandin E2, reducing inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression by 56% and 64%, respectively, in the macrophage cell line J774A.1. | [in vivo]
Apigenin (4',5,7-Trihydroxyflavone), a natural flavonoid, possesses a broad spectrum of biological properties, including antioxidative, anti-inflammatory, anticancer, and neuroprotective effects. Apigenin (125 mg/kg and 250 mg/kg) alleviates Adriamycin (ADR) (24 mg/kg)-induced myocardial injury. Apigenin inhibits serum aspartate amino transferase (AST) release. Apigenin reduces serum lactate dehydrogenase (LDH) release. Apigenin reduces serum creatine kinase (CK) contents[4]. | [References]
[1] MASATERU YAMADA. Inhibition of protein kinase CK2 prevents the progression of glomerulonephritis.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2005, 102 21: 7736-7741. DOI: 10.1073/pnas.0409818102
[2] JIAN SHEN. Phosphorylation by the Protein Kinase CK2 Promotes Calpain-Mediated Degradation of IκBα1[J]. The Journal of Immunology, 2001, 25 1: 4919-4925. DOI: 10.4049/jimmunol.167.9.4919
[3] GIUSEPPINA MATTACE RASO. Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1[J]. Life sciences, 2001, 68 8: Pages 921-931. DOI: 10.1016/s0024-3205(00)00999-1 |
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Energy Chemical
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http://www.energy-chemical.com |
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