| Chemical Properties | Back Directory | [Boiling point ]
620.5±55.0 °C(Predicted) | [density ]
1.36±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [form ]
Solid | [pka]
12.16±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
PF-07202954 is a weakly basic DGAT2 inhibitor with an IC50 of 10 nM for human DGAT2. PF-07202954 lowers liver triglyceride content in a Western-diet-fed rat model[1]. | [References]
[1] Kevin J Filipski, et al. Design of Next-Generation DGAT2 Inhibitor PF-07202954 with Longer Predicted Half-Life. ACS Med Chem Lett. 2023 Oct 2;14(10):1427-1433. DOI:10.1021/acsmedchemlett.3c00330 |
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