| Chemical Properties | Back Directory | [Boiling point ]
547.3±45.0 °C(Predicted) | [density ]
1.219±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 10 mg/mL (27.59 mM; Need ultrasonic) | [form ]
Solid | [pka]
12.91±0.29(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
CDK5-IN-3 (compound 11) is a potent and selective CDK5 inhibitor, with IC50s of 0.6 nM and 18 nM for CDK5/p25 and CDK2/CycA, respectively. CDK5-IN-3 can be used for the research of autosomal dominant polycystic kidney disease (ADPKD)[1]. | [IC 50]
Cdk5/p25: 0.6 nM (IC50); CDK2/CycA: 18 nM (IC50) | [storage]
Store at -20°C | [References]
[1] Discovery and Optimization of Highly Selective Inhibitors of CDK5. J Med Chem. 2022 Feb 24;65(4):3575-3596. DOI:10.1021/acs.jmedchem.1c02069 |
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