| Identification | Back Directory | [Name]
1H-Thieno[3,4-d]imidazole-4-pentanamide, N-[5-[[(5Z,11α,13E,15S)-11,15-dihydroxy-1,9-dioxoprosta-5,13-dien-1-yl]amino]pentyl]hexahydro-2-oxo-, (3aS,4R,6aS)- | [CAS]
2641624-60-2 | [Synonyms]
1H-Thieno[3,4-d]imidazole-4-pentanamide, N-[5-[[(5Z,11α,13E,15S)-11,15-dihydroxy-1,9-dioxoprosta-5,13-dien-1-yl]amino]pentyl]hexahydro-2-oxo-, (3aS,4R,6aS)- | [Molecular Formula]
C35H58N4O6S | [MOL File]
2641624-60-2.mol | [Molecular Weight]
662.93 |
| Chemical Properties | Back Directory | [Boiling point ]
930.5±65.0 °C(Predicted) | [density ]
1.150±0.06 g/cm3(Predicted) | [solubility ]
DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): .1 mg/ml | [form ]
Liquid | [pka]
13.79±0.60(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Prostaglandin E2 (PGE2) is the major eicosanoid product of cyclooxygenase-1 and 2 in epithelial cells, leukocytes, reproductive tissues, and many others. PGE2 contracts smooth muscle, protects the gastric mucosa, modulates immune function, and regulates fertility and implantation. PGE2 acts through at least four 7-transmembrane G protein-coupled receptors, EP1-EP4. PGE2-biotin is an affinity probe which allows PGE2 to be detected through an interaction with the biotin ligand. PGE2-biotin was designed to allow PGE2 to be detected in complexes with transmembrane receptors and/or nucleic acid or protein binding partners. It is thus a tool to be used in the general elucidation of the mechanism of action of PGs. | [Uses]
Prostaglandin E2-biotin is a prostaglandin analog. Prostaglandin E2-biotin can be used for research of Nurr1-related disease, such as cancer and autoimmune disease[1]. | [References]
[1] Yoon C, et al. Prostaglandin analogs and uses thereof. US20210139435A1. 2021-05-13. |
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