| Identification | Back Directory | [Name]
4-Pyrimidinamine, 2-(4-bromophenyl)-6-chloro-5-(2-methoxyphenoxy)- | [CAS]
2643300-54-1 | [Synonyms]
DHPS-IN-1
4-Pyrimidinamine, 2-(4-bromophenyl)-6-chloro-5-(2-methoxyphenoxy)- | [Molecular Formula]
C17H13BrClN3O2 | [MOL File]
2643300-54-1.mol | [Molecular Weight]
406.66 |
| Chemical Properties | Back Directory | [Boiling point ]
408.9±45.0 °C(Predicted) | [density ]
1.527±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
0.81±0.10(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
DHPS-IN-1, with the best DHPS inhibitory potency (IC50 = 0.014 μM), exhibits excellent inhibition against melanoma cells. | [References]
[1] Liu KL, et al. Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma: Design, Synthesis, and Biological Evaluation. J Med Chem. 2021 Sep 23;64(18):13356-13372. DOI:10.1021/acs.jmedchem.1c00582 |
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