| Identification | Back Directory | [Name]
2-Naphthalenol, 4-[4-(3,8-diazabicyclo[3.2.1]oct-3-yl)-5,8-dihydro-2-[[1-(4-morpholinylmethyl)cyclopropyl]methoxy]pyrido[3,4-d]pyrimidin-7(6H)-yl]-5-iodo- | [CAS]
2648221-12-7 | [Synonyms]
KRAS G12D inhibitor 16
2-Naphthalenol, 4-[4-(3,8-diazabicyclo[3.2.1]oct-3-yl)-5,8-dihydro-2-[[1-(4-morpholinylmethyl)cyclopropyl]methoxy]pyrido[3,4-d]pyrimidin-7(6H)-yl]-5-iodo- | [Molecular Formula]
C32H39IN6O3 | [MOL File]
2648221-12-7.mol | [Molecular Weight]
682.59 |
| Hazard Information | Back Directory | [Uses]
KRAS G12D inhibitor 16 is a KRAS G12D inhibitor. KRAS G12D inhibitor 16 has inhibitory activity against KRAS G12D and KRAS G12D mutation with IC50 value of 0.7 nM and 0.35 μM, respectively. KRAS G12D inhibitor 16 can be used for the research of many malignant tumor, such as pancreatic ductal adenocarcinomas (PDAC), colon and rectal carcinomas (CRC), non-small cell lung carcinomas (NSCLC)[1]. | [IC 50]
KRas G12D: 0.7 nM (IC50) | [References]
[1] Yuichi Kawai, et al. A compound having inhibitory activity against kras g12d mutation. Patent. WO2021107160A1. |
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