| Identification | Back Directory | [Name]
2-Piperazineacetonitrile, 4-[7-(3-methoxy-1-naphthalenyl)-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[2,3-d]pyrimidin-4-yl]-1-(1-oxo-2-propen-1-yl)-, (2S)- | [CAS]
2648808-69-7 | [Synonyms]
KRAS G12C inhibitor 43
2-Piperazineacetonitrile, 4-[7-(3-methoxy-1-naphthalenyl)-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[2,3-d]pyrimidin-4-yl]-1-(1-oxo-2-propen-1-yl)-, (2S)- | [Molecular Formula]
C33H35N7O3 | [MOL File]
2648808-69-7.mol | [Molecular Weight]
577.68 |
| Hazard Information | Back Directory | [Uses]
KRAS G12C inhibitor 43 (compound 59) is a potent KRAS G12C inhibitor. KRAS G12C inhibitor 43 shows antimigration and anti-proliferative activity with IC50s of 0.001-1 μM, >1 μM, >1 μM for H358, A549, HCC cells ,respectively[1]. | [IC 50]
KRas G12C | [References]
[1] Xu Wei, et al. Pyridopyrimidine kras g12c mutant protein inhibitor. WO2021139678A1. |
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