| Identification | Back Directory | [Name]
1-Pyrrolidinecarboxylic acid, 2-[(3-pyridinylamino)carbonyl]-, 2-(4-nitrobenzoyl)hydrazide, (2R)- | [CAS]
2649120-22-7 | [Synonyms]
CDK4/6-IN-8
1-Pyrrolidinecarboxylic acid, 2-[(3-pyridinylamino)carbonyl]-, 2-(4-nitrobenzoyl)hydrazide, (2R)- | [Molecular Formula]
C18H18N6O5 | [MOL File]
2649120-22-7.mol | [Molecular Weight]
398.37 |
| Hazard Information | Back Directory | [Uses]
CDK4/6-IN-8 (Compound 7p) is a selective CDK4 and CDK6 inhibitor with IC50 values of 5.01 nM and 3.97 nM, respectively[1]. | [IC 50]
CDK6: 3.97 nM (IC50); CDK4: 5.01 nM (IC50) | [References]
[1] Liang JW, et al. Synthesis and identification of a novel skeleton of N-(pyridin-3-yl) proline as a selective CDK4/6 inhibitor with anti-breast cancer activities. Bioorg Chem. 2022 Feb;119:105547. DOI:10.1016/j.bioorg.2021.105547 |
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