| Identification | Back Directory | [Name]
2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDIN-4(5H)-ONE | [CAS]
26493-11-8 | [Synonyms]
2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDIN-4(5H)-ONE
Thiazolo[5,4-c]pyridin-4(5H)-one, 2-amino-6,7-dihydro-
2-amino-6,7-dihydro-5H-[1,3]thiazolo[5,4-c]pyridin-4-one
2-Amino-5,6,7,7a-tetrahydro-3aH-thiazolo[5,4-c]pyridin-4-one | [Molecular Formula]
C6H7N3OS | [MDL Number]
MFCD14706760 | [MOL File]
26493-11-8.mol | [Molecular Weight]
169.2 |
| Chemical Properties | Back Directory | [Boiling point ]
559.4±39.0 °C(Predicted) | [density ]
1.487±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [pka]
13.47±0.20(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
Step i: Deprotection reaction of tert-butyl 2-amino-4-oxo-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate
To a 50 mL round bottom flask was added tert-butyl 2-amino-4-oxo-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate (0.7 g, 0.0026 mol) and 1,4-dioxane (10 mL). Subsequently, a 1,4-dioxane solution of 4 M hydrochloric acid (10 mL) was added to the same flask. The reaction mixture was stirred at room temperature for 3 hours. After completion of the reaction, the volatile solvent was removed by distillation under reduced pressure to give the crude product. The solid was washed with ether to afford purified 2-amino-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one (0.4 g, 96% yield).LC-MS analysis showed the molecular ion peak of the target compound as 169.9 [M + H]+. | [References]
[1] Patent: WO2015/101928, 2015, A1. Location in patent: Page/Page column 66; 67
[2] Patent: WO2011/73339, 2011, A1. Location in patent: Page/Page column 42 |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Wuhan Topule
|
| Tel: |
+86-02787215551 +86-19945035818 |
| Website: |
http://www.topule.com/ |
|