| Chemical Properties | Back Directory | [Boiling point ]
850.659±75.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.369±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [solubility ]
Acetonitrile: soluble | [form ]
A solid |
| Hazard Information | Back Directory | [Description]
Posaconazole-d5 is intended for use as an internal standard for the quantification of posaconazole by GC- or LC-MS. Posaconazole is a broad-spectrum triazole antifungal agent active against various yeasts and molds, including Aspergillus, Candida, Fusarium, and Zygomycetes.1 Posaconazole inhibits the growth of fungi by inhibiting the lanosterol 14α-demethylase enzyme (IC50s = 7-200 nM), which results in a disruption in the synthesis of ergosterol , a key sterol necessary for fungal cell membrane integrity and for the function of certain membrane-bound proteins.2 | [References]
1. Herbrecht, R., Nivoix, Y., Fohrer, C., et al. Management of systemic fungal infections: Alternatives to itraconazole J. Antimicrob. Chemother. 56(Suppl 1),i39-i48(2005).
2. Munayyer, H.K., Mann, P.A., Chau, A.S., et al. Posaconazole is a potent inhibitor of sterol 14α-demethylation in yeasts and molds Antimicrob. Agents Chemother. 48(10),3690-3696(2004). |
|
|