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2650846-59-4

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2650846-59-4 Structure

2650846-59-4 Structure

Identification	Back Directory
[Name] OSM-S-106
[CAS] 2650846-59-4
[Synonyms] OSM-S-106
[Molecular Formula] C12H10N4O2S2
[MOL File] 2650846-59-4.mol
[Molecular Weight] 306.37

Chemical Properties	Back Directory
[Boiling point ] 645.960±65.00 °C(Press: 760.00 Torr)(predicted)
[density ] 1.563±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
[form ] Solid
[pka] 9.847±0.60(predicted)
[color ] White to off-white

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[Uses] OSM-S-106 is a pro-inhibitor and that inhibition of PfAsnRS occurs via enzyme-mediated production of an Asn-OSM-S-106 adduct. OSM-S-106 inhibits protein translation and activates the amino acid starvation response. OSM-S-106 exhibits selective activity against Plasmodium blood and liver stages and low intrinsic clearance by human microsomes[1].
[References] [1] Xie SC, et al. Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Preprint. Res Sq. 2023;rs.3.rs-3198291. Published 2023 Jul 27. DOI:10.21203/rs.3.rs-3198291/v1

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