| Chemical Properties | Back Directory | [Boiling point ]
645.960±65.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.563±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
9.847±0.60(predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
OSM-S-106 is a pro-inhibitor and that inhibition of PfAsnRS occurs via enzyme-mediated production of an Asn-OSM-S-106 adduct. OSM-S-106 inhibits protein translation and activates the amino acid starvation response. OSM-S-106 exhibits selective activity against Plasmodium blood and liver stages and low intrinsic clearance by human microsomes[1]. | [References]
[1] Xie SC, et al. Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Preprint. Res Sq. 2023;rs.3.rs-3198291. Published 2023 Jul 27. DOI:10.21203/rs.3.rs-3198291/v1 |
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