| Identification | Back Directory | [Name]
Pyrazolo[1,5-a]-1,3,5-triazin-4-amine, 8-cyclopropyl-N-[(6,7-difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-morpholinyl)- | [CAS]
2651196-69-7 | [Synonyms]
CDK12-IN-4
Pyrazolo[1,5-a]-1,3,5-triazin-4-amine, 8-cyclopropyl-N-[(6,7-difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-morpholinyl)- | [Molecular Formula]
C20H20F2N8O | [MOL File]
2651196-69-7.mol | [Molecular Weight]
426.42 |
| Hazard Information | Back Directory | [Uses]
CDK12-IN-4, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC50 of 0.641 μM at high ATP (2 mM). CDK12-IN-4 has no effect on CDK2/Cyclin E (IC50>20 μM) and CDK9/Cyclin T1 (IC50>20 μM) at high ATP (2 mM) (WO2021116178A1)[1]. | [IC 50]
CDK12: 0.641 μM (IC50); CDK2/cyclinE: >20 μM (IC50); CDK9/cyclinT1: >20 μM (IC50) | [References]
[1] Kai Thede, et al. Pyrazolotriazines. WO2021116178A1. |
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