| Hazard Information | Back Directory | [Uses]
CDK12-IN-6, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC50 of 1.19 μM at high ATP (2 mM). CDK12-IN-6 has no effect on CDK2/Cyclin E (IC50>20 μM) and CDK9/Cyclin T1 (IC50>20 μM) at high ATP (2 mM) (WO2021116178A1)[1]. | [IC 50]
CDK12: 1.19 μM (IC50); CDK2/cyclinE: >20 μM (IC50); CDK9/cyclinT1: >20 μM (IC50) | [References]
[1] Kai Thede, et al. Pyrazolotriazines. WO2021116178A1. |
|
|