ChemicalBook--->CAS DataBase List--->2653349-51-8

2653349-51-8

Request For Quotation

Directory

Chemical Properties

Hazard Information

2653349-51-8 Structure

2653349-51-8 Structure

Identification	Back Directory
[Name] S16–1029
[CAS] 2653349-51-8
[Synonyms] S16–1029
[Molecular Formula] C23H25N7O3
[MOL File] 2653349-51-8.mol
[Molecular Weight] 447.49

Chemical Properties	Back Directory
[density ] 1.45±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka] 13.56±0.70(predicted)

Hazard Information	Back Directory
[Uses] S16–1029 is a selective and orally active butyrylcholinesterase (BChE) inhibitor with IC50s of 11.35 nM and 48.1 nM for eqBChE and hBChE, respectively. S16–1029 could cross the blood-brain barrier (BBB) and reach the central nervous system (CNS). S16–1029 can be used for Alzheimer's disease (AD) research[1].
[IC 50] eqBCHE: 11.35 nM (IC₅₀); hBCHE: 48.1 nM (IC₅₀)
[References] [1] Shuaishuai Xing, et al. Optimizing drug-like properties of selective butyrylcholinesterase inhibitors for cognitive improvement: Enhancing aqueous solubility by disrupting molecular plane. Eur J Med Chem. 2024 Mar 2:268:116289. DOI:10.1016/j.ejmech.2024.116289

2653349-51-8 suppliers list

Company Name:	TargetMol Chemicals Inc.
Tel:	15002134094
Website:	https://www.targetmol.cn/

Tags:2653349-51-8 Related Product Information