| Identification | Back Directory | [Name]
N,N-(1,4-phenylene)bis(4-chlorobenzenesulfonamide) | [CAS]
2654-68-4 | [Synonyms]
Compound F0433-0067
N,N-(1,4-phenylene)bis(4-chlorobenzenesulfonamide)
Benzenesulfonamide, N,N'-1,4-phenylenebis[4-chloro- | [Molecular Formula]
C18H14Cl2N2O4S2 | [MDL Number]
MFCD00183149 | [MOL File]
2654-68-4.mol | [Molecular Weight]
457.35 |
| Hazard Information | Back Directory | [Uses]
hiCE inhibitor-1, a sulfonamide derivative, is a selective human intestinal enzyme (hiCE) inhibitor with a Ki value of 53.3 nM. hiCE inhibitor-1 can be used to improve Irinotecan (HY-16562)-induced diarrhoea[1]. | [References]
[1] Randy M Wadkins, et al. Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of irinotecan-induced diarrhea: synthesis, quantitative structure-activity relationship analysis, and biological activity. Mol Pharmacol. 2004 Jun;65(6):1336-43. DOI:10.1124/mol.65.6.1336 |
|
|